Karl Fischer titration: difference between revisions
Diff·revision 23 → 24·02:06, 28 Jul 2025
Difference between revision 23 and revision 24 of Karl Fischer titration. 3 lines changed; the page grew by 435 bytes.
| Revision 23 — 21:59, 4 Jul 2025 Retention_Time_Rae (talk) add the reference standard and its traceability 8,306 bytes +357 | Revision 24 — 02:06, 28 Jul 2025 NPOV_Nadia (talk) space between number and unit per PP:MOS 8,741 bytes +435 | ||
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| 83 | {{figure|vial|Cross-section of a lyophilised vial. The cake is hygroscopic and its water content is part of the labelled mass.}} | 83 | {{figure|vial|Cross-section of a lyophilised vial. The cake is hygroscopic and its water content is part of the labelled mass.}} |
| 84 | 84 | ||
| + | 85 | Community-collated reports suggest that water content is among the least frequently reported fields on certificates accompanying research peptides, with purity reported far more often than the mass-balance terms that would make purity interpretable.{{r|ppcommunity}} | |
| + | 86 | ||
| 85 | == Relationship to other methods == | 87 | == Relationship to other methods == |
| 86 | {{seealso|Loss on drying|Analytical method validation}} | 88 | {{seealso|Loss on drying|Analytical method validation}} |
| ⋮ | ⋮ | ||
| 91 | <ref name="usp1503">United States Pharmacopeia, General Chapter <1503>, "Quality Attributes of Synthetic Peptide Drug Substances" (informational). USP–NF, current revision.</ref> | 93 | <ref name="usp1503">United States Pharmacopeia, General Chapter <1503>, "Quality Attributes of Synthetic Peptide Drug Substances" (informational). USP–NF, current revision.</ref> |
| 92 | <ref name="scholz1984">Scholz E. ''Karl Fischer Titration: Determination of Water''. Springer, Berlin (1984). The standard monograph on reagent chemistry and interferences.</ref> | 94 | <ref name="scholz1984">Scholz E. ''Karl Fischer Titration: Determination of Water''. Springer, Berlin (1984). The standard monograph on reagent chemistry and interferences.</ref> |
| + | 95 | <ref name="ppcommunity">PeptidePedia certificate-field tally, 2026 (self-reported community submissions; weak evidence — see [[Project:Sourcing_guidelines]]).</ref> | |
| 93 | 96 | ||
| 94 | == Further reading == | 97 | == Further reading == |