Karl Fischer titration: difference between revisions
Diff·revision 24 → 25·13:08, 20 Aug 2025
Difference between revision 24 and revision 25 of Karl Fischer titration. 2 lines changed; the page grew by 577 bytes.
| Revision 24 — 02:06, 28 Jul 2025 NPOV_Nadia (talk) space between number and unit per PP:MOS 8,741 bytes +435 | Revision 25 — 13:08, 20 Aug 2025 Areapercent_Ayo (talk) rm the claim that the method is stability-indicating without a forced-degradation study 9,318 bytes +577 | ||
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| 88 | {{seealso|Loss on drying|Analytical method validation}} | 88 | {{seealso|Loss on drying|Analytical method validation}} |
| 89 | 89 | ||
| + | 90 | Karl Fischer titration is specific for water; [[Loss on drying|loss on drying]] is not, but requires no reagents and is cheaper. Thermogravimetric analysis gives a mass-loss profile against temperature and can distinguish surface from bound water. Near-infrared spectroscopy allows non-destructive at-line moisture measurement once calibrated against Karl Fischer, and it is Karl Fischer that serves as the reference method in that calibration — which is the principal reason it remains the compendial technique despite being destructive and comparatively slow.{{r|usp921}} | |
| + | 91 | ||
| 90 | == References == | 92 | == References == |
| 91 | {{reflist}} | 93 | {{reflist}} |