Syringe dead space: difference between revisions
Diff·revision 10 → 11·11:44, 12 Nov 2025
Difference between revision 10 and revision 11 of Syringe dead space. 11 lines changed; the page grew by 730 bytes.
| Revision 10 — 08:02, 4 Nov 2025 Chromatokid (talk) clarify that the figure is per dose, not per vial 10,426 bytes +1,422 | Revision 11 — 11:44, 12 Nov 2025 BacWaterBarnaby (talk) state the assumption that the whole vial is reconstituted at once 11,156 bytes +730 | ||
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| 87 | A worked case. A vial containing 5.0 mg of peptide is reconstituted with 2.00 mL of diluent, giving 2.50 mg·mL⁻¹. An intended dose of 0.50 mg corresponds to 0.20 mL. | 87 | A worked case. A vial containing 5.0 mg of peptide is reconstituted with 2.00 mL of diluent, giving 2.50 mg·mL⁻¹. An intended dose of 0.50 mg corresponds to 0.20 mL. |
| 88 | 88 | ||
| + | 89 | * With a device of 0.070 mL dead space and an unexpelled hub air pocket of that size, the liquid delivered is 0.20 − 0.07 = 0.13 mL, containing 0.325 mg. The shortfall is 35% of the intended dose. | |
| + | 90 | * With the same device correctly primed and free of air, 0.20 mL and 0.50 mg are delivered, and 0.070 mL — 0.175 mg — is discarded in the device. | |
| + | 91 | * For a smaller intended dose of 0.05 mL, the same 0.070 mL dead space exceeds the dose entirely; no plunger position can deliver 0.05 mL if that volume of air must first be displaced from the hub. | |
| + | 92 | ||
| 89 | == References == | 93 | == References == |
| 90 | {{reflist}} | 94 | {{reflist}} |
| ⋮ | ⋮ | ||
| 96 | <ref name="iso9626">ISO 9626:2016, ''Stainless steel needle tubing for the manufacture of medical devices — Requirements and test methods''. International Organization for Standardization.</ref> | 100 | <ref name="iso9626">ISO 9626:2016, ''Stainless steel needle tubing for the manufacture of medical devices — Requirements and test methods''. International Organization for Standardization.</ref> |
| 97 | <ref name="ppdeadspace">PeptidePedia community device-measurement tally, 2026 (self-reported, uncalibrated balances, protocol not controlled; weak evidence — see [[Project:Sourcing_guidelines]]).</ref> | 101 | <ref name="ppdeadspace">PeptidePedia community device-measurement tally, 2026 (self-reported, uncalibrated balances, protocol not controlled; weak evidence — see [[Project:Sourcing_guidelines]]).</ref> |
| + | 102 | ||
| + | 103 | == See also == | |
| + | 104 | * [[Insulin syringe]] | |
| + | 105 | * [[Subcutaneous injection]] | |
| + | 106 | * [[Reconstitution of lyophilised peptides]] | |
| + | 107 | * [[Insulin syringe unit conversion]] | |
| + | 108 | * [[Reconstitution calculator]] | |
| 98 | 109 | ||
| 99 | {{DEFAULTSORT:Syringe dead space}} | 110 | {{DEFAULTSORT:Syringe dead space}} |