Enteroendocrine L cell: difference between revisions
Diff·revision 4 → 5·21:58, 13 Aug 2024
Difference between revision 4 and revision 5 of Enteroendocrine L cell. 3 lines changed; the page grew by 397 bytes.
| Revision 4 — 17:56, 29 Jul 2024 DPP4_Dagmar (talk) the numbers in the lead disagreed with the body; body was right 2,224 bytes ±0 | Revision 5 — 21:58, 13 Aug 2024 GradientGus (talk) fix the anchor on an internal link 2,621 bytes +397 | ||
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| 3 | L cells are open-type endocrine cells — their apical surface is exposed directly to the intestinal lumen, allowing direct contact with nutrients and bacterial metabolites. This arrangement is in contrast to closed-type endocrine cells, which do not face the lumen. The L-cell lineage differentiates from intestinal stem cells under the influence of specific transcription factors including neurogenic regulatory elements.{{r|furness2013}} | 3 | L cells are open-type endocrine cells — their apical surface is exposed directly to the intestinal lumen, allowing direct contact with nutrients and bacterial metabolites. This arrangement is in contrast to closed-type endocrine cells, which do not face the lumen. The L-cell lineage differentiates from intestinal stem cells under the influence of specific transcription factors including neurogenic regulatory elements.{{r|furness2013}} |
| 4 | 4 | ||
| + | 5 | L cells are sparse in the duodenum and jejunum but become progressively more frequent in the ileum, where they account for approximately 1% of epithelial cells. They are most abundant in the distal ileum and right colon, positions that allow them to sense the end products of colonic bacterial fermentation, particularly short-chain fatty acids.{{r|holst2007}} | |
| + | 6 | ||
| 5 | == Morphology and distribution == | 7 | == Morphology and distribution == |
| 6 | L cells are polarised epithelial cells with microvilli on the apical surface and secretory granules in the basolateral cytoplasm. The apical surface, open to the lumen, serves as the nutrient-sensing compartment; the basolateral surface contains receptors and ion channels that relay signals to the secretory machinery. L cells represent approximately 0.5–1% of all intestinal epithelial cells overall but are far more frequent in the ileum and colon than the duodenum.{{r|furness2013}} | 8 | L cells are polarised epithelial cells with microvilli on the apical surface and secretory granules in the basolateral cytoplasm. The apical surface, open to the lumen, serves as the nutrient-sensing compartment; the basolateral surface contains receptors and ion channels that relay signals to the secretory machinery. L cells represent approximately 0.5–1% of all intestinal epithelial cells overall but are far more frequent in the ileum and colon than the duodenum.{{r|furness2013}} |
| ⋮ | ⋮ | ||
| 16 | [[Category:Incretin biology]] | 18 | [[Category:Incretin biology]] |
| 17 | [[Category:Gastrointestinal physiology]] | 19 | [[Category:Gastrointestinal physiology]] |
| + | 20 | [[Category:Receptor pharmacology]] | |
| 18 | 21 |