Vial: difference between revisions
Diff·revision 17 → 18·02:22, 30 Mar 2025
Difference between revision 17 and revision 18 of Vial. 2 lines changed; the page grew by 550 bytes.
| Revision 17 — 13:49, 11 Mar 2025 CounterfeitCato (talk) split §Cold chain from §Storage after receipt 17,729 bytes ±0 | Revision 18 — 02:22, 30 Mar 2025 StopperingSteff (talk) add the reconstitution-stability sentence with its storage condition 18,279 bytes +550 | ||
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| 120 | Ferrule designs differ in how the closure is later opened. A plain ferrule fully covers the stopper and must be removed with a decapping tool. A flip-off design carries a plastic button over a pre-cut aperture, which is lifted away to expose the central area of the stopper for needle penetration while leaving the crimp intact — the arrangement almost universal for injectable products and for research peptide vials. Colour of the button is a manufacturer's identification device with no standardised meaning, and it is not a reliable indicator of contents.{{r|iso8362_5}} | 120 | Ferrule designs differ in how the closure is later opened. A plain ferrule fully covers the stopper and must be removed with a decapping tool. A flip-off design carries a plastic button over a pre-cut aperture, which is lifted away to expose the central area of the stopper for needle penetration while leaving the crimp intact — the arrangement almost universal for injectable products and for research peptide vials. Colour of the button is a manufacturer's identification device with no standardised meaning, and it is not a reliable indicator of contents.{{r|iso8362_5}} |
| 121 | 121 | ||
| + | 122 | Two consequences bear on handling. Once a flip-off button is removed, the exposed stopper surface is no longer protected, and its disinfection before each penetration is the compendially expected practice for multiple-dose containers. And the crimp is not intended to be removed and replaced; a vial whose ferrule shows evidence of having been decapped and recrimped has an unknown seal history, which is a recognised indicator in the examination of suspected [[Repackaging|repackaged]] or [[Counterfeit peptide|counterfeit]] material.{{r|usp1207}} | |
| + | 123 | ||
| 122 | == References == | 124 | == References == |
| 123 | {{reflist}} | 125 | {{reflist}} |