Trial data comparison: difference between revisions
Diff·revision 8 → 9·03:12, 24 Feb 2025
Difference between revision 8 and revision 9 of Trial data comparison. 7 lines changed; the page grew by 439 bytes.
| Revision 8 — 00:47, 10 Feb 2025 Ref_Desk_Ron (talk) add the caveat that concentration and dose are not the same quantity 2,396 bytes +176 | Revision 9 — 03:12, 24 Feb 2025 MergeMorwenna (talk) correct the column header — that column is volume 2,835 bytes +439 | ||
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| 20 | Filter by compound, trial programme or endpoint type. The bar is drawn to the magnitude of the primary result and is scaled within its endpoint type only. | 20 | Filter by compound, trial programme or endpoint type. The bar is drawn to the magnitude of the primary result and is scaled within its endpoint type only. |
| 21 | 21 | ||
| + | 22 | == Why the estimand matters == | |
| + | 23 | {{main|Intention-to-treat analysis}} | |
| + | 24 | ||
| + | 25 | A weight-change endpoint can be summarised in at least two defensible ways, and the ICH E9(R1) addendum names them.{{r|ich9r1}} | |
| + | 26 | ||
| + | 27 | The '''treatment-policy estimand''' asks what happened to everyone randomised, including those who stopped the drug and those who started another one. It answers "what does prescribing this achieve", and it is the more conservative figure. | |
| + | 28 | ||
| 22 | == References == | 29 | == References == |
| 23 | {{reflist}} | 30 | {{reflist}} |