Trial data comparison: difference between revisions
Diff·revision 20 → 21·08:46, 14 Sep 2025
Difference between revision 20 and revision 21 of Trial data comparison. 5 lines changed; the page grew by 485 bytes.
| Revision 20 — 15:56, 21 Aug 2025 ConsensusConal (talk) expand §Why the estimand matters 6,038 bytes +235 | Revision 21 — 08:46, 14 Sep 2025 MTC_Marisol (talk) expand §Outcome trials are a different kind of evidence 6,523 bytes +485 | ||
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| 56 | '''Comparator.''' Placebo-controlled and active-controlled trials answer different questions. A placebo-adjusted difference and an absolute change are frequently confused; see [[Placebo-adjusted effect]]. | 56 | '''Comparator.''' Placebo-controlled and active-controlled trials answer different questions. A placebo-adjusted difference and an absolute change are frequently confused; see [[Placebo-adjusted effect]]. |
| 57 | 57 | ||
| + | 58 | == Outcome trials are a different kind of evidence == | |
| + | 59 | {{seealso|SELECT trial|FLOW trial|LEADER trial}} | |
| + | 60 | ||
| + | 61 | Three of the rows report hazard ratios for clinical events rather than changes in a measurement. These are the strongest evidence in the table and the least comparable to the rest of it: an event-driven trial reports a relative risk over years in a population selected for risk, and a hazard ratio cannot be placed alongside a percentage weight change in any meaningful ordering. | |
| + | 62 | ||
| 58 | == References == | 63 | == References == |
| 59 | {{reflist}} | 64 | {{reflist}} |