Incretin effect: difference between revisions
Diff·revision 17 → 18·23:05, 20 Mar 2025
Difference between revision 17 and revision 18 of Incretin effect. 2 lines changed; the page grew by 343 bytes.
| Revision 17 — 17:11, 26 Feb 2025 SchematicScout (talk) clarify that concentrations differ substantially between assay platforms 5,425 bytes ±0 | Revision 18 — 23:05, 20 Mar 2025 SatietySunniva (talk) the glucose-dependence of the insulinotropic effect deserves its own sentence 5,768 bytes +343 | ||
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| 31 | where {{math|I_{\text{oral}}}} is the integrated insulin secretion over 2–3 hours following oral glucose, and {{math|I_{\text{iv}}}} is that following intravenous glucose at matched glucose kinetics.{{r|nauck2018}} | 31 | where {{math|I_{\text{oral}}}} is the integrated insulin secretion over 2–3 hours following oral glucose, and {{math|I_{\text{iv}}}} is that following intravenous glucose at matched glucose kinetics.{{r|nauck2018}} |
| 32 | 32 | ||
| + | 33 | Measurement requires both an oral glucose-tolerance test and a euglycaemic-hyperglycaemic clamp on separate days. Because the clamp is labour-intensive and requires careful blood sampling, the incretin effect is not routinely measured in clinical practice; it is a research tool for mechanistic investigations and for assessing drug effects. | |
| + | 34 | ||
| 33 | == References == | 35 | == References == |
| 34 | {{reflist}} | 36 | {{reflist}} |