Incretin effect: difference between revisions
Diff·revision 13 → 14·20:01, 24 Dec 2024
Difference between revision 13 and revision 14 of Incretin effect. 5 lines changed; the page grew by 197 bytes.
| Revision 13 — 14:42, 29 Nov 2024 TesamorelinTeg (talk) add the postprandial time course with its units 4,982 bytes ±0 | Revision 14 — 20:01, 24 Dec 2024 AmylinAmos (talk) close an unbalanced quotation mark 5,179 bytes +197 | ||
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| 24 | GLP-1 is secreted by L cells of the distal small intestine and colon, in response to glucose, fat and amino acids. Its plasma half-life is approximately 2 minutes due to rapid inactivation by [[Dipeptidyl peptidase-4]]. GIP is secreted earlier, by K cells of the duodenum and proximal jejunum, and has a half-life of approximately 7 minutes. The two hormones act through distinct receptors on beta cells; both couple to adenylyl cyclase and raise intracellular cAMP, but through non-identical signalling cascades, and each contributes approximately equally to the total incretin effect in health.{{r|nauck2018}} | 24 | GLP-1 is secreted by L cells of the distal small intestine and colon, in response to glucose, fat and amino acids. Its plasma half-life is approximately 2 minutes due to rapid inactivation by [[Dipeptidyl peptidase-4]]. GIP is secreted earlier, by K cells of the duodenum and proximal jejunum, and has a half-life of approximately 7 minutes. The two hormones act through distinct receptors on beta cells; both couple to adenylyl cyclase and raise intracellular cAMP, but through non-identical signalling cascades, and each contributes approximately equally to the total incretin effect in health.{{r|nauck2018}} |
| 25 | 25 | ||
| + | 26 | == Quantification and measurement == | |
| + | 27 | The incretin effect is usually quantified as a percentage: | |
| + | 28 | ||
| + | 29 | {{math|\text{Incretin effect} = (I_{\text{oral}} - I_{\text{iv}}) / I_{\text{oral}} \times 100\%}} | |
| + | 30 | ||
| 26 | == References == | 31 | == References == |
| 27 | {{reflist}} | 32 | {{reflist}} |