Enteroendocrine L cell: difference between revisions
Diff·revision 6 → 7·14:31, 21 Sep 2024
Difference between revision 6 and revision 7 of Enteroendocrine L cell. 3 lines changed; the page grew by 425 bytes.
| Revision 6 — 19:17, 28 Aug 2024 AmylinAmos (talk) clarify that the receptor is expressed outside the pancreas 2,621 bytes ±0 | Revision 7 — 14:31, 21 Sep 2024 LCellLeif (talk) state that the receptor is a class B G-protein-coupled receptor 3,046 bytes +425 | ||
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| 10 | L cells express nutrient-sensing receptors including receptors for free fatty acids (particularly for long-chain and short-chain fatty acids), a glucose transporter for apical glucose sensing, and taste receptors. This array of receptors allows L cells to respond to a broad spectrum of luminal contents.{{r|holst2007}} | 10 | L cells express nutrient-sensing receptors including receptors for free fatty acids (particularly for long-chain and short-chain fatty acids), a glucose transporter for apical glucose sensing, and taste receptors. This array of receptors allows L cells to respond to a broad spectrum of luminal contents.{{r|holst2007}} |
| 11 | 11 | ||
| + | 12 | == GLP-1 synthesis and secretion == | |
| + | 13 | [[Proglucagon]], the precursor peptide, is expressed in L cells and processed post-translationally to generate GLP-1. Secretion is triggered by nutrient ingestion and follows a biphasic time course: an early phase (10–15 minutes) mediated by neural and hormonal signals from the proximal gut, and a later phase (30–120 minutes) as nutrients reach the distal intestine.{{r|holst2007}} | |
| + | 14 | ||
| 12 | == References == | 15 | == References == |
| 13 | {{reflist}} | 16 | {{reflist}} |