Enteroendocrine L cell: difference between revisions
Diff·revision 17 → 18·14:45, 20 Jun 2025
Difference between revision 17 and revision 18 of Enteroendocrine L cell. 3 lines changed; the page grew by 435 bytes.
| Revision 17 — 07:37, 14 May 2025 SurpassSunniva (talk) add short description 4,648 bytes ±0 | Revision 18 — 14:45, 20 Jun 2025 AmylinAmos (talk) rm the sentence implying the hormone is a drug 5,083 bytes +435 | ||
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| 20 | L cells are continuously regenerated from intestinal stem cells in the intestinal crypts, with a typical lifespan of 3–5 days for a mature L cell. Factors influencing L-cell differentiation include specific transcription-factor pathways, growth factors from neighbouring cells, and signalling molecules from the microbiota.{{r|biemin2019}} | 20 | L cells are continuously regenerated from intestinal stem cells in the intestinal crypts, with a typical lifespan of 3–5 days for a mature L cell. Factors influencing L-cell differentiation include specific transcription-factor pathways, growth factors from neighbouring cells, and signalling molecules from the microbiota.{{r|biemin2019}} |
| 21 | 21 | ||
| + | 22 | == Clinical significance == | |
| + | 23 | L cells are the primary target of [[GLP-1 receptor agonist|GLP-1-directed therapeutics]], which work by mimicking or enhancing the action of GLP-1 released from these cells. Understanding L-cell biology has informed drug development and has identified therapeutic opportunities for enhancing endogenous GLP-1 secretion or L-cell mass expansion, approaches currently under investigation in clinical trials. | |
| + | 24 | ||
| 22 | == References == | 25 | == References == |
| 23 | {{reflist}} | 26 | {{reflist}} |